INBDE (Integrated National Board Dental Examination) Practice Exam

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Prepare for the INBDE (Integrated National Board Dental Examination) exam. Study with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

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AA is able to kill human PMNs due to its production of what?

Hyaluronidase
Collagenase
Leukotoxin
Gingipain

The correct answer is: Leukotoxin

AA is able to kill human polymorphonuclear leukocytes (PMNs) due to its production of leukotoxin. Leukotoxin is a virulence factor produced by Aggregatibacter actinomycetemcomitans (AA), a pathogen associated with periodontal disease. Leukotoxin specifically targets and kills human PMNs, which are important components of the immune system's defense against bacterial infections in the oral cavity. By producing leukotoxin, AA can evade the immune response and contribute to the progression of periodontal disease. Option A (Hyaluronidase), Option B (Collagenase), and Option D (Gingipain) are enzymes produced by other periodontal pathogens like Porphyromonas gingivalis. While these enzymes play roles in tissue destruction and pathogenicity in periodontal disease, they are not specifically associated with the ability of AA to kill human PMNs, making them incorrect choices for this question.